ea0013p147 | Diabetes, metabolism and cardiovascular | SFEBES2007
Kusminski Christine
, Kos Katarina
, Schraw Todd
, OHare Joseph
, Ahima Rexford
, Scherer Philipp
, Kumar Sudhesh
, McTernan Philip
Aims/hypothesis: Adiponectin is an adipocyte-derived secretory factor that is highly specifically expressed in adipocytes. It exerts effects on energy homeostasis via peripheral and central mechanisms. However, it is not clear whether adiponectin is crossing the blood brain barrier in humans. In serum, adiponectin circulates in several different complexes, each of which has distinct functions. Here, we wanted to test whether adiponectin can be found in human cerebrospinal flui...